ABSTRACT
The radiographic features of an intraosseous lesion are usually associated with the biological behavior of the tumor. In view of the fact that the growth and behavior of keratocystic odontogenic tumors (KCOT) is mainly associated with the proliferation of the cystic epithelium, the objective of the present study was to evaluate the relationship between cell proliferation markers and radiographic features of this tumor. Thirty-seven radiographs of KCOT obtained from 30 patients were scanned and evaluated on a monitor. Sections were submitted to immunohistochemistry for Ki-67, p63, and p53 proteins on an EnVision system. Thirty-one KCOTs were observed in the posterior of the mandible, and the unilocular aspect was predominant (n= 26). Nineteen KCOTs distorted the mandibular canal and 11 displaced teeth. Satellite cysts were associated with a multilocular aspect (P= 0.016). p53 was in KCOTS with diffuse margins (p=0.049), p63 with NBCCS (p=0.049) KOT and higher KI-67 positive cells was observed in KCOTs presenting distortion of the mandibular canal (p=0.042). The distribution of Ki-67, p63, and p53 positive cells was similar between KCOTs with uni- and multilocular aspects. The results of the present study suggest that cell proliferation in KCOT contributes to the radiographic features of this tumor.
Las características radiográficas de una lesión intraósea se asocian generalmente con el comportamiento biológico del tumor. Debido a esto, el crecimiento y comportamiento de los tumores odontogénicos queratoquísticos se asocian principalmente con la proliferación del epitelio quístico. El objetivo del estudio fue evaluar la relación entre los marcadores de proliferación celular y las características radiológicas de este tumor. Se escanearon y evaluaron 37 radiografías de tumores odontogénicos queratoquísticos obtenidos de 30 pacientes y las secciones de sus biopsias fueron sometidas a evaluación inmunohistoquímica para las proteíneas Ki-67, p63 y p53 en un sistema Envision. Se observaron 31 tumores odontogénicos queratoquísticos en el área posterior de la mandíbula, con predominio del aspecto unilocular (n= 26). Diecinueve tumores odontogénicos queratoquísticos distorsionaron el canal mandibular y se observaron 11 dientes desplazados. Los quistes satélites se asociaron con el aspecto multilocular (P= 0,016). La distribución de células positivas para Ki-67, p63 y p53 fue similar entre tumores odontogénicos queratoquísticos con aspectos uniformes y multiloculares, y no estaban relacionadod con la distorsión del canal mandibular (P>0,05) o con el desplazamiento del diente (P>0,05). Los resultados del presente estudio sugieren que la proliferación celular en tumores odontogénicos queratoquísticos contribuye a las características radiográficas de este tumor.
Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Young Adult , Odontogenic Tumors/pathology , Odontogenic Tumors/diagnostic imaging , Immunohistochemistry , Radiography , Odontogenic Cysts , Biomarkers, Tumor , Cell ProliferationABSTRACT
Purpose: The present study aimed to review a series of ameloblastoma cases by observing their clinicopathological and demographic characteristics. The data in this study were compared to previous studies. Methods: Seventy ameloblastoma cases were obtained from the archive of the Surgical Pathology Service of the Dental School of the Federal University of Bahia and were analyzed with regards to age, gender, clinical manifestation, radiographic aspect, anatomical distribution and histological subtype. These data were submitted to statistical analysis. Results: Of the 70 cases, 35 (50%) occurred in males and 35 (50%) in females. Young adults were most affected by tumors. Fifty-six (80%) of all tumor cases occurred in the jaw. The main histological subtype seen was unicystic ameloblastoma, which occurred in 35 cases. The majority of the tumors [n=57 (81.4%)] were treated with radical surgery. The differences in clinical aspects and anatomical distribution were shown to be statistically significant (P<0.001).Conclusion: The clinical-epidemiological profile of the patients in the present study is similar to that in other populations, with unicystic ameloblastoma being the most common histological subtype seen.
Objetivo: O presente estudo se propôs a revisar uma série de casos de ameloblastomas, observando-se as suas características clinicopatológicas e demográficas. Adicionalmente, os dados foram comparados com estudos prévios.Metodologia: Setenta casos de ameloblastomas foram recuperados dos arquivos do serviço de Patologia Cirúrgica da Faculdade de Odontologia da Universidade Federal da Bahia e analisados quanto a idade, sexo, manifestação clínica, aspecto radiográfico, distribuição anatômica e subtipo histológico. Esses dados foram submetidos à análise estatística.Resultados: Dos 70 casos, 35 (50%) acometeram o sexo masculino e 35 (50%) o sexo feminino. Os adultos jovens foram os mais afetados pelos tumores. A mandíbula foi o sítio preferencial, correspondendo a 56 casos (80%) do total dos tumores analisados. O principal subtipo histológico encontrado foi o ameloblastoma unicístico, que acorreu em 35 casos. A maioria dos tumores [n=57 (81,4%)] foi tratada cirurgicamente de forma radical. Dados em relação ao aspecto clínico e distribuição anatômica apresentaram-se estatisticamente significantes (P<0,001). Conclusão: O perfil clínico- epidemiológico dos pacientes do presente estudo é similar ao de outras populações, sendo que o ameloblastoma unicístico é o subtipo histológico mais comum em nossa população.